iStability® MKT

"Revised USP standards for product dating, packaging, and temperature monitoring", CC Okeke, L Bailey, T Medwick, and LT Grady, American Journal of Health-System Pharmacy, Vol 57, Issue 15, 1441-1445.

This article contains two data sets with manually calculated mean kinetic temperatures. This page presents additional validation information by comparing the mean kinetic temperatures computed by iStability® MKT with those listed in this article.

Data Set 1

Mean of the highest and lowest temperatures for each week over a period of 52 weeks was 25 °C (i.e., the same mean for each week). The manually calculated mean kinetic temperature with an activation energy of 83.144 kJ/ mole as reported in the article is 25 °C.

The mean kinetic temperature computed by iStability® MKT is shown in the screenshot below:

Data Set 2

The following low and high temperatures of 12 intervals are used:

Temperature (°C)
Interval Low High
1 15 27
2 20 25
3 17 25
4 20 25
5 22 27
6 15 25
7 20 26
8 22 26
9 23 27
10 20 28
11 20 24
12 22 28

The manually calculated mean kinetic temperature with an activation energy of 83.144 kJ/mole as reported in the article is 23.01 °C.

The mean kinetic temperature computed by iStability® MKT is shown in the screenshot below:

Conclusion

For both data sets, the calculated mean kinetic temperatures are the same from two independent sources.


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